Sébastien Talbot, Ph.D.
Tier-2 Canada Research Chair, Chair in Neuro-Immunology 2017-2022
Assistant Professor, Université de Montréal. July 2017-
Faculty of Medicine. Dept of Pharmacology and Physiology.
My laboratory integrates neuroscience and immunology, which is a novel and highly dynamic field, and combines techniques of molecular and cell biology, optogenetics, tissue clearance and imaging, electrophysiology, neuroanatomy, behavior, and genetics. My goal is to identify the mechanisms and molecules that regulate the interplay between the immune and sensory nervous systems in physiology and pathology. Among the others, I will investigate: 1) the capacity of nociceptors to sense allergens, 2) the role of nociceptor neurons in cancer immunosurveillance, and 3) how nociceptors control fibrosis.
Tier-2 Canada Research Chair in Neuro-Immunology 2017-2022
Canadian Institutes of Health Research
Canada Foundation of Innovation, John R. Evans Leaders fund Pending
Université de Montréal startup fund. 2017-2022
Ph. D. in Physiology, Université de Montréal, Canada 2006-2012
Thesis title: Localization, induction mechanism and pathophysiological role of kinin B1 receptor in experimental model of pain in the rat.
B. Sc. in Pharmacology, Université de Sherbrooke, Canada 2003-2006
PREVIOUS RESEARCH EXPERIENCE
Postdoctoral training, Boston Children’s Hospital, USA 2012-2017
Mentor: Dr Clifford J. Woolf. Harvard Medical School. Dept. of Neurobiology
Main focus: Development of mice models of nociceptor ablated mice and validation of pharmacological compounds (charged voltage gated sodium channel blocker and charged calcium channel blocker) to specifically silence pain neurons subjected to inflammation. Highlight the importance of nociceptors as key drivers of allergic airway inflammation.
Internship, Pontifical Catholic University of Rio Grande do Sul, Brazil 2011-2012
Mentor: Dr Maria Martha Campos. Dept. of Pharmacology
Main focus: Validate the use of kinin B1 receptor knockout mice in diabetic pain neuropathy. Highlight the key role of kinin B1 receptor in diabetic pain-induced microgliosis.
Graduate studies, Université de Montréal, Canada 2006-2012
Mentor: Dr Réjean Couture. Dept. of Pharmacology and Physiology
Main focus: Development of a fluorescent agonist to specifically localize kinin B1 receptor in the rat CNS. Validation of a kinin B1 receptor non-peptidic and selective antagonists in a rat model of diabetic pain neuropathy. Establish a rat 3D lung primary culture cell method to assess lung inflammation and fibrosis when exposed to cigarette smoke. Unravelling the mechanism of induction, the cellular localization and pathophysiological role of kinin B1 receptor in experimental rat models of pain and inflammation.
Postdoctoral fellowship, Canadian Institutes of Health Research (CIHR) 2014-2017
Postdoctoral fellowship, Fonds Recherche en Santé du Québec (FRQS) 2012-2014
“Timely completion of Ph.D. studies” Scholarship 2012
Université de Montréal (UdeM)
Michael Smith Foreign Study Supplement, CIHR 2011-2012
Ph. D. fellowship, CIHR 2009-2012
Frederick Banting and Charles Best Canada graduate scholarship
Ph. D. fellowship, FRQS 2008-2009
Fellowship for accelerated passage to the Ph.D, UdeM 2007-2009
M. Sc. fellowship, FRQS 2008-2009
Undergraduate internship scholarship, FRQS 2005
B. Sc. excellence scholarship 2003-2006
Association des Universités et Collèges du Canada
Technology development fund award, Boston Children’s hospital 2016
Dean’s Honor list (Ph. D. thesis), UdeM 2012
Thesis defense ranked in the top 5% of the year, UdeM 2012
Awards for excellence in Ph. D. studies, UdeM 2008-2010
Jacques Genest best presentation award 2008
Club de Recherches Cliniques du Québec
The General Governor’s medal, Government of Canada. 1999-2000