Photo. Talbot.JPG

Sébastien Talbot, Ph.D.

Tier-2 Canada Research Chair, Chair in Neuro-Immunology    2017-2022

Assistant Professor, Université de Montréal.                                    July 2017-

Faculty of Medicine. Dept of Pharmacology and Physiology.

My laboratory integrates neuroscience and immunology, which is a novel and highly dynamic field, and combines techniques of molecular and cell biology, optogenetics, tissue clearance and imaging, electrophysiology, neuroanatomy, behavior, and genetics. My goal is to identify the mechanisms and molecules that regulate the interplay between the immune and sensory nervous systems in physiology and pathology. Among the others, I will investigate: 1) the capacity of nociceptors to sense allergens, 2) the role of nociceptor neurons in cancer immunosurveillance, and 3) how nociceptors control fibrosis.


RESEARCH FUNDING

 

Tier-2 Canada Research Chair in Neuro-Immunology                                                   2017-2022

Canadian Institutes of Health Research

Canada Foundation of Innovation, John R. Evans Leaders fund                                       Pending

Université de Montréal startup fund.                                                                               2017-2022


EDUCATION

Ph. D. in Physiology, Université de Montréal, Canada                                                       2006-2012

Thesis title: Localization, induction mechanism and pathophysiological role of kinin B1 receptor in experimental model of pain in the rat.

B. Sc. in Pharmacology, Université de Sherbrooke, Canada                                                  2003-2006


PREVIOUS RESEARCH EXPERIENCE

Postdoctoral training, Boston Children’s Hospital, USA                                              2012-2017

Mentor: Dr Clifford J. Woolf. Harvard Medical School. Dept. of Neurobiology

Main focus: Development of mice models of nociceptor ablated mice and validation of pharmacological compounds (charged voltage gated sodium channel blocker and charged calcium channel blocker) to specifically silence pain neurons subjected to inflammation. Highlight the importance of nociceptors as key drivers of allergic airway inflammation.

Internship, Pontifical Catholic University of Rio Grande do Sul, Brazil                       2011-2012

Mentor: Dr Maria Martha Campos. Dept. of Pharmacology

Main focus: Validate the use of kinin B1 receptor knockout mice in diabetic pain neuropathy. Highlight the key role of kinin B1 receptor in diabetic pain-induced microgliosis.

Graduate studies, Université de Montréal, Canada                                                      2006-2012

Mentor: Dr Réjean Couture. Dept. of Pharmacology and Physiology

Main focus: Development of a fluorescent agonist to specifically localize kinin B1 receptor in the rat CNS. Validation of a kinin B1 receptor non-peptidic and selective antagonists in a rat model of diabetic pain neuropathy. Establish a rat 3D lung primary culture cell method to assess lung inflammation and fibrosis when exposed to cigarette smoke.  Unravelling the mechanism of induction, the cellular localization and pathophysiological role of kinin B1 receptor in experimental rat models of pain and inflammation.


FELLOWSHIPS

Postdoctoral fellowship, Canadian Institutes of Health Research (CIHR)        2014-2017

Postdoctoral fellowship, Fonds Recherche en Santé du Québec (FRQS)           2012-2014

“Timely completion of Ph.D. studies” Scholarship                                    2012

Université de Montréal (UdeM)

Michael Smith Foreign Study Supplement, CIHR                                      2011-2012 

 Ph. D. fellowship, CIHR                                                                             2009-2012

Frederick Banting and Charles Best Canada graduate scholarship                    

Ph. D. fellowship, FRQS                                                                              2008-2009

Fellowship for accelerated passage to the Ph.D, UdeM                              2007-2009

M. Sc. fellowship, FRQS                                                                              2008-2009

 Undergraduate internship scholarship, FRQS                                           2005                

B. Sc. excellence scholarship                                                                      2003-2006

Association des Universités et Collèges du Canada 


AWARDS


Technology development fund award, Boston Children’s hospital                              2016

Dean’s Honor list (Ph. D. thesis), UdeM                                                                2012

Thesis defense ranked in the top 5% of the year, UdeM                                        2012

Awards for excellence in Ph. D. studies, UdeM                                                      2008-2010                               

Jacques Genest best presentation award                                                                  2008

Club de Recherches Cliniques du Québec     

The General Governor’s medal, Government of Canada.                                           1999-2000